Born at Bologna, Lucia Mannucci relocated to Milan at a very young age. She attend the Art of Movement school directed by Carla Strauss.
She successfully auditioned for EIAR, the Italian national radio broadcasting company, and worked as a singer for the various radio orchestras. She toured Italy for some years, working with the such entertainers as Gorni Kramer, Natalino Otto, and the Quartetto Cetra.
On August 19, 1944, she married Virgilio Savona, one of the singers of the Quartetto Cetra. Three years later, she also joined the quartet, replacing Enrico De Angelis.
Lucia Mannucci was the only female member of Quartetto Cetra, but she also had a great solo voice.
Besides working with Quartetto Cetra, Lucia Mannucci pursued a solo career as singer, musical actress, and TV show hostess. She and her husband also did research on folk music.